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Users are always advised to avoid over dosing due to the potential negative reactions such as respiratory depression and impaired judgment. Most of the illicit drug emergency room visits involved multiple drugs.

The primary factor contributing to death was cited as MDPV toxicity after autopsy was performed. Schedule I status is reserved for those substances with a high potential for abuse, no currently accepted use for treatment in the United States and a lack of accepted safety for use of the drug under medical supervision.

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Also, these behavioural changes are related to alterations of factor expression directly related to addiction. It also specifically includes MDPV, misspelling the full name as "methyenedioxypyrovalerone".

However, as MDMA, animals adapted faster to the repeated social isolation [13] Long-term effects[ edit ] Although there is no experience about the long-term effects of MDPV in humans, its has been reported that mice treated with MDPV during adolescence show reinforcing behavior patterns to cocaine which are higher than the control group.

This condition is known as temporal disintegration. A purported reason was the appearance of high potency cannabis.

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